@RoGeorge
It's not only release from pressure. Heat of vaporization plays a factor when very low boiling liquids are used.
@? dermatologists
A lot use liquid nitrogen, which can be applied by sprayers or on swabs.
1,2-dichloroethane was used years ago in dermatology and for local freezing. I don't know if it still is used. I use 1,1-difluoroethane, which is common in dusters that are not just compressed air. I use a bitterant free version called "Gust." Its availability probably varies by state. It is also flammable.
CO2 from compressed cylinders (like used to power airguns, Crosman brand) can be used, but that is probably more expensive. Larger CO2 cylinders as used in the beverage industry are far less expensive but bulky. My "man lift" uses them.
Finding something that is non-flammable, cold enough, not too cold, can be easily stored for long periods, doesn't contain non-volatile additives, and doesn't cause cancer if you live in California is difficult. CO2 meets many of those requirements.