Typically in that situation I've found that you probably forgot to connect something. The DRC just looks to find basic problems that would cause issues (things too close together, traces from different nets that are connected, etc...). The LVS is what actually looks at you schematic and makes sure that you're faithfully recreated that in your layout. If you look at your Output button on the LVS window it will give you more detailed information on its analysis of your design. If there are no smoking guns there then I find it most useful to look at the extracted view where Cadence adds net numbers to all of the devices. If two points should be connected to the same net, but the net listed in the extracted view is different then you've found a problem and now you know at least the first thing to fix. I've seen plenty of occasions where 1 missing connection can cause dozens of LVS errors so don't get discouraged.