Not "zero effort", but definitely "low effort":
For the backside, I sometimes press the (soldered) PCB into corrugated cardboard, then deepen the dimles a bit with the backside of a for or tweezers so the majority of the PCB touches the still flat part of the cardboard. Then you can apply a bit of glue around the edges.
You can also make surprisingly good enclosures out of empty milk or juice cartons. These things are made of very high quality cardboard and the laminated plastic on both sides make it water and dirt resistant. You can cut it with scissors or a knife, and you can press folding ribs into it with a ballpoint.
Another method I use is:
1. Enter labels in a spreadsheet program
2. Adjust the line height to 2.54mm
3. Reduce font size so it's readably
4. Print it on paper.
5. Put transparent tape over it.
6. Glue it onto the PCB.
You can even "level out" an uneven PCB (for example containing SMT parts) with hot glue and then put the paper on top.
For prototypes you often wand some sort of feet to keep your PCB from shorting out form small metal pieces lying on your desk, while still keeping the backside accessible for soldering. You can put generous dots of hot glue in the corner, then hold it briefly under running water. This makes the outer layer of the glue hard and non-stick, while the inside is still soft. Then you can set the PCB on a flat surface. this will get the feet to the same height (because the still hot inside of the blob deforms) while the outside is cold enough so you can remove it easily. Doing this on a dusty or otherwise dirty surface also helps to prevent sticking.
I also have some projects in a very dirty environment, but also out of sight. For example behind the kitchen stove. An area that becomes sticky with grease if not often cleaned. Such projects I simply put in a plastic bag and then tie the opening shut. I have an extension cord so both the hot water kettle and the coffee maker share the same wall plug, and I had the RCD trip twice because of a few drops of water spilled on the extension cord. So I also put a plastic bag over the extension cord sockets and closed it. Only the power cords come out one end.