Also don't fall into the trap of premature optimization. Gain and offset corrections are nice features, but the whole idea is they just save a few CPU cycles.
Just start by using the values as-is. If you need calibration, do it in software, less need to read and understand manuals, more control about what happens.
Only if you actually have a performance issue, then think about utilizing in-peripheral processing features.
Regarding the fixed-point value, it might be easier if you just think about it as a number, where 1024 corresponds to exactly 1.0, and 2048 would correspond to exactly 2.0. 0 would correspond 0. It's a simple linear system. If you need 1.1, that would be approximately 1024+102.