What DavidAlfa mentions is that indeed some USB3 host controllers (PC side) are more finicky with non-fully-compliant USB2 devices, and many claimed USB2 devices are actually not fully compliant, so that's why you *may* occasionally have troubles with some (poorly designed) USB2 devices when connected to a USB3 port. USB2-only host controllers tend to be more forgiving. This is a "known" issue, not saying of course that's the case with the CH340, but it can be with those fake FT232R chips.