you mean taking the output of an optimizing compiler and optimizing it even further?
again, that's going to take a human, probably.
Because the human can actually understand context, the big picture, and apply tricks the compiler can't guarantee for (or it would use them).
The problem is, the output of an optimizing compiler, at higher levels, can create partterns that are difficult to analyze, and further optimize. And a human capable of doing that would probably not bother, he would rewrite the thing in assembly directly.
In any case, it usually doesn't matter. A program can be divided in logic and stuff that doesn't need to happen at microsecond rate and time critical code that can be optimized, but usually the compiler already does a good job, or the time critical code is rewritten in assembly.
However, if you mean to take an autogenerated mess (such as the clusterfuck generated by MCC, or crap from "AI") and convert it to efficient code... automated tools will never make it. Just hire/become a competent developer.