0xFFFF'FFFD is not a real address, and the processor does not really jump to it, so, no, you cannot put a breakpoint there.
It's a special marker, called EXC_RETURN that's used in the Arm architecture to tell the CPU to pop an exception (i.e., loosely, an interrupt or fault or service request) stack frame.
Its lower bits encode the information on which stack to use, whether to return to Handler or Thread modes, and whether the stack frame includes FP registers to restore.
See table 2.17 in chapter 2.3.7 of the
Cortex M4 Generic User Guide - this is for M4, an M0(+) - I seem to remember you are using one? - does not have FP, so only
three values are used.
Specifically, 0xFFFF'FFFD returns to Thread Mode - exceptions switch automatically to Handler Mode if the processor is not already in that mode - restores the registers from an exception stack frame (see the preceding sections in either manual) kept in the Process Stack Pointer (PSP), meaning generally that this exception was triggered in Thread Mode, and select PSP as the stack pointer in use from that moment on.
EtA: A good debugger knows about it, and will show where in the code you are supposed to return, using the info in the stack frame. Put a BP at the end of the ISR.