Dual or Triple footprints for the RAM? (Wide DIP, Narrow DIP, SMT)
How big is the board? One of the things that I get hung up on, recently, is a desire to make things fit reasonably efficiently within the cheap PCB sizes available from Itead/etc. So if you exceed 50x100mm, you're better going to 100x100mm than 80x125mm (for example.)
I have some spare 552s lying around as well. It used to be used on the cisco Environmental Controller board, and their batteries went bad often, and the tech was replaced when flash became common...