If you disconnect R5, then the value of R4 should be decreased to 15K (same as R1) to maintain CMRR.
However even if you do that, the output of the opamp will be biased at 0V. Since the opamp is single-supply, it won't work properly in this condition. So you need to bias the output above GND (like with R5) or use a dual supply for the opamp.
Thanks for reaching out!

looks like I fell into a trap for young players...
CMRR is what bit me in the simulation.
A single supply opamp is all i have in this case (by design).
For this application (current shunt, only positive currents) I'm trying to maximize dynamic range.
[I don't really care about negative current much, that's only due to my approximation of the ripple current for simulation purposes.]
Assuming for the lowest currents I need to measure the opamp can follow with it's [minimum] output swing, would you still bias OP+ input to lift the output signal from GND thus sacrificing dynamic range?
(i.e. R5 = 300k, R4 = R2 = 30k )
EDIT: I've not been able to calculate the CMRR when using the difference amp topology with bias.
If anyone can point me in the right direction or link to some example calculations, that'd be great!