Yeah, from what I've seen, PCB printing errors are either small tolerance, or large blobs. The printing itself is repeatable within a few mils (for the cheaper manufacturers), so by printing alone, 4 mil rules would be pushing it, but 6 or 7 mils is several sigma and pretty safe to do. The blob defects aren't so easy to deal with, being up to 100 mil across, perhaps? I think the cause is poor adhesion of film/resist/plating, so an area flakes off. Not like a density/porosity/speckle thing.
So you could probably deal with flaking defects with *really* large design rules, like 100mil+, but that's terrifically impractical for almost everything else.
Tim