Hi Justin,
I can't answer everything here, but here's a few answers:
1 - Difficult. I'd start by at least confirming voltages and currents such as the supply voltage to the LM3886 IC.
3 - Those dotted lines are a polyline, usually used to define the borders of a ground plane. Try right-clicking on one, then choose rename (choose all segments) and re-name it to GND. This should fill the empty space with a ground plane. The smaller inner polyline seems to be defining a "keep-out" area.
4 - There's a dimension tool in Eagle (fourth button from the bottom on the left) which you can use to measure the PCB.
A few further questions on getting it working / diagnosing: What are you powering the PCB with? Have you a proper split rail supply for it? How many amps are the two rails pulling? What signal are you injecting into the amp to test it?
A further tip: The LM3886 has that massive tab on the back for a reason - It gets hot, very hot when working. Strap a big heatsink to it, otherwise it won't be working for very long when you do get it up and running.
McBryce.