I haven't tried the latest scopes, but I have an Agilent 7014A which includes hardware decode of serial streams and can therefore trigger on I2C addresses, etc.
It's a pleasure to use and good at what it does .. but it doesn't replace the Saleae. The ease of skimming through long captures and decoding multiple streams on a PC screen (even though the Saleae has very crude triggering and searching) can't be compared with trying to pan and zoom through the Agilent's smaller capture memory.
I wouldn't be without a proper benchtop scope and I think mixed-signal analysis is a great addition. But don't expect it to replace the little $100 Saleae for protocol analysis. (Yes, i know you can get the cloned hardware for $5. It's the software, and a platform to run it with fast video updates and well-designed mouse controls that makes it good).