Duh, easy.
Make sure the ram module is properly plugged in.
If you think it is, and the computer still tells you it only has 2 GB then you have to investigate.
Take out the memory modules, put one at a time in the slot and see what the computer says. If the computer doesn't start with one of the modules, try the module in another slot. Try all four slots.
If a module worked before but this module doesn't work in any slot, it's probably dead or the contacts are burned out or oxydated. Get some isopropyl alcohol and a paper towel or something, wet the towel and rub the gold contacts of the memory. Dry it out, then try the memory again in all slots. Still not working? It's dead, Jim.
If both modules work separately (only one put in pc in the first slot or a particular slot), but you don't see in bios 4 GB or the value you're supposed to see when you put both modules in pc, change the slot of the second memory you add, try each slot.
If it works in another slot, the slot may be dirty or the clips are loose, or the ram contacts are dirty and the ram module slots may also be a bit dirty so a connection just happens to be poor enough to make your module not work. With the computer turned off, blow some air inside the memory slot, clean the ram contacts as described above, try again.
Motherboard should work with the ram modules in any slot you want, but for optimum speed it's recommended to put them as it says in manual 1-3 or 2-4 or 1-2, 3-4 whichever is the dual channel layout.