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I've made a great many such panels using just these tools; like with anything worth doing, prep makes all the difference. You start by laying it out with a good rule, Sharpie and a scribe to get perfect lines. You COULD use Dy-Kem Blue if you happen to dabble in lathe work, but Sharpie is a lot cheaper. 
Then you make a ~10mm hole close to each corner, and start nibbling. There ARE electric-powered equivalents to these, but for precise openings they just don't offer enough control. First you nibble the corners square, then start nibbling around the perimeter right next to, but NOT on the scribed line. The closer you get, the less file work you'll have later. Cut as much as you can from the BACK of the work for the cleanest lines; but sometimes you just HAVE TO cut from the front. Make allowances for this when laying out.
Last week I made the front panel for my "HV" supply (yes it is still not finished). It needed a 9x9 cm² cutout for the 2 panel meters (it would have needed 2 9x4.5 cm² ones, but I was cutting corners). At first I wanted to use my nibbler, but shied away fearing to bend the thin aluminum sheet. So I used my fretsaw.

The meter's bezels will hide the ragged edges.
The file work is where patience really pays off. you'll use a 12-16" (size of work surface) single-cut mill (type with smooth diagonal cutting edges) bastard (fineness of cut between COARSE and 2nd CUT) file. For big jaggies you'll knock the high points down by push or pull filing towards the BACK of the work. This makes all your burr edges manifest on the back edge. Pull-filing helps to mitigate the file snagging on edges and "hopping" which can scar up the work edges, or worse, the face of the panel. You want to clamp the metal so the vise is as close to the surface you are cutting as possible; this eliminates flex-induced movement of the work that will also cause "hopping".
Filing is where I shine. NOT! I
did learn filing in vocational school ("Berufsschule" - had to look this one up), but I did not really learn it (I hated it). My father was a mechanician, but he didn't show me either.
This video is a good quick & clear primer on files & how to choose & care for them. 
I will watch it right now during breakfast, I promise!
And I decided to trash the panel and buy a new housing, since not only the panel is crap; the whole housing is awful. I still had it laying around and cheap as I am, thought I'd put it to use.
I picture myself standing at the vise for weekend after weekend ... ending up with turd.
