I once experimented with this in a blue afternoon and I have gotten it to a working state under Linux. I did have to solder on the extra SPI flash memory. I think I only flashed an image onto it with an ST-Link, and after a reset It showed up in my file system, and I could read python files and write a new python file to it too.
I did find it sort of cute, but I do not have much interest in programming python (and especially for uC's) and that test was all I ever did with it.