I would agree with the problems mentioned with the GQ-4X programmer. I have had all kinds of issues programming and reading various parts on the GQ-4X programmer, so much so that I refuse to use it any more. My most recent experience was with an AMD 29LV160 flash part - when reading the part I get different data depending on whether the speed was set to 0, +1, or +2. The TL866 programmer read it fine every time. I've also had numerous problems reading Dallas NVRAMs that are used in the Tek TDS600/700 scopes.
The contents of the DS1250 are not critical, as others have mentioned it only stores saved waveforms and saved user settings. In fact, the scope will boot just fine if you completely remove the DS1250. The original DS1650 that was used in these scopes is long obsolete, but the DS1250 works fine as a substitute. I've replaced dozens of these parts in various TDS600/700 series scopes.
The DS1486 is much more important - it actually holds the scope options as well as the date & time. These parts went obsolete in the 2010 time frame as I recall. You can buy these parts on Ebay, but they are fake. I know this because some of these parts will have a datecode of 2014 or newer! I've also verified that the some of the mechanical dimensions of these fake parts are also out of spec, another indication that they are not authentic. For example, the pin length on the fake China parts are longer than what the Maxim spec indicates. These parts might work okay, but I question for how long. I do plan to start a new thread on an analysis of some of these fake parts, but just haven't had the time yet.