Still working on the routing, It breaks a lot of conventions I'm used to, everything has to be planned as a differential current loop to prevent any kind of cross talk or interference with the measurement, meaning there are vastly different requirements for how quiet the ground should be for a given area, e.g. R35 seems like you would just connect it to the same ground as the analog filter, but that is not quite correct, the ferrite beads ground needs to be well away from it as its switching significant currents compared to the sensitivity of the system and its performance does not effect the measurement at all, its just giving that current somewhere to flow, and how the input filter needs to be almost directly at the input of U11, as that is the only place it forms a current loop with ground,
As far as I can see, the analog ground used for the integrator needs to be treated like a differential return all the way back to J2, with the references referenced off that point. but leaving something having to be done about all the current from the zener... I', slowly unwrapping it all, but I can see why people say laying out these boards can be harder than designing them. I suppose once its built up into a well planned block it will be a reusable module, but wow does this strain the brain.
In these type of circuits, how much effort is generally put to having ground planes on the reverse side of the board overlap the chips, as that could increase power supply noise coupling in, but I would imagine the shielding being a bigger benefit.
Or have I accidentally started trying to design far better than is actually required?